Octenidine Dihydrochloride

Octenidine HCL or better referred to as Octenidine Dihydrochloride is a lively surfactant thats cationic in nature. Octenidine features a Gemini surfactant structure and is a derivative from pyridine. The finest part about Octenidine HCL is its active nature against gram-negative and gram-positive bacteria. Octenidine HCL or Octenidine Dihydrochloride is safe to handle, chemically stable and not inflammable. It is used for the treatment of wound infections and for disinfecting the skin and mucous membrane.

Since the year 1987, the compound has been utilized in the manufacturing of antiseptic and anti-bacterial products. It gained a lot of ground in terms of popularity, especially in all over Europe next to neonates.

It is an excellent substitute for Chlorhexidine, especially when used in a concentrated form of 0.1 to 2.0%. Another aspect of this compound that makes it all the more appealing to the mass production industry is its economic factor. In other words, Octenidine HCL preparations are cheap to manufacture, design and store.

In Controlled tests, especially suspension tests of in-vitro nature over a period of 5 minutes have shown that Octenidine HCL in small amounts is perfectly capable of killing disease-causing bacteria/microbial life like:

  • Staphylococcus aureus
  • Escherichia coli
  • Proteus mirabilis and
  • Candida albicans yeast

Back in 2014, a controlled study was carried out that consisted of 17 patients who were subjected to ICU units in different hospitals in Berlin. The compound was applied on the skins of each of these patients with the goal of observing whether the compound is capable of decreasing nosocomial infection rates.

Another survey carried out in the neonatal ICUs of leading German hospitals proved that when Octenidine HCL is administered to the patients, symptoms of skin conditions like blistering, scarring and necrosis watered down.

All in all, due to its many benefits as an antibacterial and antimicrobial compound, Octenidine HCL finds extensive use within the manufacturing sector related to cosmetics and personal care products.

Product Description

Octenidine Dihydrochloride is a cationic surfactant, pyridine based molecule and is used extensively as an antiseptic for topical applications. It has been found in large area of application and is an alternative for older substances like Chlorhexidine, Polividone-iodine and Triclosan.

It is used for the topical application of Atopic Dermatitis, Wounds, Vaginal Applications, Inflated Eczema, Acne, and Herpes and for controlling multidrug resistant pathogens.

COMPOSITION

Product Name Octenidine Dihydrochloride
CAS No. 70775-75-6
EINECS No. 274-861-8
Chemical Name N,N'-[Decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene]bis(Octylammonium) Dichloride
Chemical Formula C 36 H 64 C 12 N 4
Molecular Weight 623.83
Synonyms N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine dihydrochloride.
N,N'-(decane-1,10-diyldipyridin-1-yl-4-ylidene)dioctan-1-amine dihydrochloride
Structure Octenidine Dihydrochloride

Technical Data

Description Parameter
Appearance White to off white powder
Identification
1) Infrared Spectroscopy
2) HPLC

Matches with the standard
The retention time of the sample matches with the standard
Moisture NMT 2.0%
Related Substances by HPLC
1) 4-Octyl Amino pyridine
2) Unknown individual impurity
3) Total impurities

NMT 0.1%
NMT 0.1%
NMT 0.5%
Purity (on dry basis) 98% - 100%

Concentration

0.1 - 2.0%

Storage

Store in a cool dry area. Protect it from extreme heat conditions.

Expiry Date

2 years from the date of manufacturing.

Packaging

25 kg HDPE bags or carton